AGENTIAL BIOLOGY INSTITUTE
1st Annual Pre-Conference on Substrate-Grounded Intelligence
October 3-4, 2026 · Boston, MA · By invitation · No attendance fee · travel stipend available
About the meeting
PLACEHOLDER TEXT Biology has been read for half a century as an information-processing story in which the organism is the output of its code and intelligence is a late arrival. The Agential Biology Institute takes the opposite starting point: that agency is foundational rather than emergent, and that living systems bind meaning to their own physical circumstances in ways that may not be substrate-neutral.
This pre-conference gathers a small group of biologists, physicists, cyberneticians, philosophers and AI researchers to ask what follows from that premise: how meaning is bound in organismic intelligence, whether biology is reducible to fitness functions, what distinguishes computation programmed in silico from computation running in vivo, and whether digital systems bind meaning at all. The aim is not to settle these questions but to establish the intellectual parameters of the field they define, and to leave with tractable proposals for how agency might actually be tested.
Convened in the spirit of the 1946-53 cybernetics conferences: small, cross-disciplinary, argumentative, and organised around shared definitional work rather than the presentation of finished results.
Keynotes
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Attendees
Karl Friston
University College London
Michael Levin
Tufts University
Thomas Parr
University of Oxford
Oded Rechavi
Tel-Aviv University
Katherine Kauffman
EFS International
Esther Dyson
Josh Bongard
University of Vermont
Steven Lehar
Harvard University
Andrew Briggs
University of Oxford
Eloi Camprubi-Casas
University of Texas
Rio Grande Valley
Charlie Munford
Agential Biology Institute
John Cumbers
SynBioBeta
Denis Noble
University of Oxford
Richard Watson
Agential Biology Institute
Joel Dietz
MIT & Bioelectricity.net
Stuart Kauffman
University of Pennsylvania
Anthony Finbow
Agential Biology Institute
Zach Schlosser
The Divinity School
Perry Marshall
Evolution 2.0 Prize
Dina Rudick
Agential Biology Institute
Olaf Witkowski
Cognisee
Eloi Camprubi-Casas
University of Texas
Rio Grande Valley
Joana Xavier
Agential Biology Institute
Questions on the table
Sessions will be built around a small number of open problems. The current shortlist:
How is meaning bound in organismic intelligence?
Is biology reducible to fitness functions?
Are there real differences between the computation programmable in silico and the computation running in vivo?
Do digital computers bind meaning at all?
What are the intellectual parameters of this field of study?
How do we develop workable tests of agency?
Format
The meeting is built around discussion rather than lectures. Each session opens with a short provocation and moves directly into structured argument, with a rapporteur charged with producing something usable by the end of it.
Participants circulate brief position notes in advance. Sessions are closed; the aim is a working ontology, a shortlist of candidate experiments, and a research agenda that participating labs can act on.
Venue & travel
Venue — Boston, MA. Venue to be confirmed.
Accommodation — A block of rooms will be held at a hotel near the venue. Details to follow.
Cost — There is no attendance fee. A travel stipend is available to invited participants; meals during the meeting are covered.
Inquiries
For questions about the program, attendance, or partnership, write to charlie@agentialbiology.org, or use the form below.