AGENTIAL BIOLOGY INSTITUTE

1st Annual Pre-Conference on Substrate-Grounded Intelligence

October 3-4, 2026 · Boston, MA · By invitation · No attendance fee · travel stipend available

About the meeting

PLACEHOLDER TEXT Biology has been read for half a century as an information-processing story in which the organism is the output of its code and intelligence is a late arrival. The Agential Biology Institute takes the opposite starting point: that agency is foundational rather than emergent, and that living systems bind meaning to their own physical circumstances in ways that may not be substrate-neutral.

This pre-conference gathers a small group of biologists, physicists, cyberneticians, philosophers and AI researchers to ask what follows from that premise: how meaning is bound in organismic intelligence, whether biology is reducible to fitness functions, what distinguishes computation programmed in silico from computation running in vivo, and whether digital systems bind meaning at all. The aim is not to settle these questions but to establish the intellectual parameters of the field they define, and to leave with tractable proposals for how agency might actually be tested.

Convened in the spirit of the 1946-53 cybernetics conferences: small, cross-disciplinary, argumentative, and organised around shared definitional work rather than the presentation of finished results.

Keynotes

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Attendees

Karl Friston
University College London

Michael Levin
Tufts University

Thomas Parr
University of Oxford

Oded Rechavi
Tel-Aviv University

Katherine Kauffman
EFS International

Esther Dyson

Josh Bongard
University of Vermont

Steven Lehar
Harvard University

Andrew Briggs
University of Oxford

Eloi Camprubi-Casas
University of Texas
Rio Grande Valley

Charlie Munford
Agential Biology Institute

John Cumbers
SynBioBeta

Denis Noble
University of Oxford

Richard Watson
Agential Biology Institute

Joel Dietz
MIT & Bioelectricity.net

Stuart Kauffman
University of Pennsylvania

Anthony Finbow
Agential Biology Institute

Zach Schlosser
The Divinity School

Perry Marshall
Evolution 2.0 Prize

Dina Rudick
Agential Biology Institute

Olaf Witkowski
Cognisee

Eloi Camprubi-Casas
University of Texas
Rio Grande Valley

Joana Xavier
Agential Biology Institute

Questions on the table

Sessions will be built around a small number of open problems. The current shortlist:

  • How is meaning bound in organismic intelligence?

  • Is biology reducible to fitness functions?

  • Are there real differences between the computation programmable in silico and the computation running in vivo?

  • Do digital computers bind meaning at all?

  • What are the intellectual parameters of this field of study?

  • How do we develop workable tests of agency?

Format

The meeting is built around discussion rather than lectures. Each session opens with a short provocation and moves directly into structured argument, with a rapporteur charged with producing something usable by the end of it.

Participants circulate brief position notes in advance. Sessions are closed; the aim is a working ontology, a shortlist of candidate experiments, and a research agenda that participating labs can act on.

Venue & travel

  • Venue — Boston, MA. Venue to be confirmed.

  • Accommodation — A block of rooms will be held at a hotel near the venue. Details to follow.

  • Cost — There is no attendance fee. A travel stipend is available to invited participants; meals during the meeting are covered.

Inquiries

For questions about the program, attendance, or partnership, write to charlie@agentialbiology.org, or use the form below.